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#* Summary statistics for PK parameters by dose group
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**Summary statistics for PK parameters by dose group of Plasma C (C) - First dose**
!TABINLINE[size:8,ignoreCaption:true,valueTable:false]
| Profile    | Group        | Name (Unit)                                       | N^a^ | Mean (SD)        | CV% mean | Geo-mean | CV% geo-mean | Median | [Min, Max]      |
| ---------- | ------------ | ------------------------------------------------- | ---- | ---------------- | -------- | -------- | ------------ | ------ | --------------- |
| First dose | 10mg_OD_Oral | AUC %Extrapolation Obs (%)                        | 9    | 10.22 (5.469)    | 53.52    | 8.433    | 85.22        | 10.78  | [2.019, 17.77]  |
|            |              | AUC %Extrapolation Pred (%)                       | 9    | 10.23 (5.501)    | 53.8     | 8.444    | 84.7         | 10.7   | [1.992, 17.07]  |
|            |              | AUC All (ug/L*h)                                  | 10   | 1328 (231.7)     | 17.45    | 1310     | 17.53        | 1317   | [1054, 1699]    |
|            |              | AUC Infinity Obs (ug/L*h)                         | 9    | 1523 (303.1)     | 19.9     | 1495     | 20.82        | 1585   | [1111, 1997]    |
|            |              | AUC Infinity Obs Norm by Dose (ug/L*h/mg)         | 9    | 152.3 (30.31)    | 19.9     | 149.5    | 20.82        | 158.5  | [111.1, 199.7]  |
|            |              | AUC Infinity Pred (ug/L*h)                        | 9    | 1523 (305.6)     | 20.06    | 1495     | 20.92        | 1572   | [1114, 2013]    |
|            |              | AUC Infinity Pred Norm by Dose (ug/L*h/mg)        | 9    | 152.3 (30.56)    | 20.06    | 149.5    | 20.92        | 157.2  | [111.4, 201.3]  |
|            |              | AUC Over Dosing Interval (ug/L*h)                 | 9    | 1357 (226)       | 16.66    | 1340     | 16.94        | 1331   | [1054, 1699]    |
|            |              | AUC Over Dosing Interval Norm by Dose (ug/L*h/mg) | 9    | 135.7 (22.6)     | 16.66    | 134      | 16.94        | 133.1  | [105.4, 169.9]  |
|            |              | AUC to Last Nonzero Conc (ug/L*h)                 | 10   | 1328 (231.7)     | 17.45    | 1310     | 17.53        | 1317   | [1054, 1699]    |
|            |              | AUC to Last Nonzero Conc Norm by Dose (ug/L*h/mg) | 10   | 132.8 (23.17)    | 17.45    | 131      | 17.53        | 131.7  | [105.4, 169.9]  |
|            |              | Average Concentration (ug/L)                      | 9    | 56.54 (9.418)    | 16.66    | 55.84    | 16.94        | 55.45  | [43.94, 70.79]  |
|            |              | Conc Trough (ug/L)                                | 9    | 15.46 (7.327)    | 47.39    | 13.37    | 69.57        | 18.63  | [4.48, 24.46]   |
|            |              | Half-Life Lambda z (h)                            | 9    | 6.75 (1.713)     | 25.38    | 6.534    | 28.53        | 7.203  | [3.897, 8.54]   |
|            |              | Last Nonzero Conc (ug/L)                          | 10   | 15.98 (7.103)    | 44.44    | 13.97    | 66.9         | 18.66  | [4.48, 24.46]   |
|            |              | Last Nonzero Conc Pred (ug/L)                     | 9    | 15.48 (7.454)    | 48.15    | 13.39    | 68.96        | 18.53  | [4.42, 25.77]   |
|            |              | Max Conc (ug/L)                                   | 10   | 111 (24.21)      | 21.8     | 108.3    | 25.07        | 113.2  | [62.33, 138.3]  |
|            |              | Max Conc Norm by Dose (ug/L/mg)                   | 10   | 11.1 (2.421)     | 21.8     | 10.83    | 25.07        | 11.32  | [6.233, 13.83]  |
|            |              | Min Conc (ug/L)                                   | 10   | 0 (0)            | -^c^     | -^d^     | -^d^         | 0      | [0, 0]          |
|            |              | Min Conc Norm by Dose (ug/L/mg)                   | 10   | 0 (0)            | -^c^     | -^d^     | -^d^         | 0      | [0, 0]          |
|            |              | Number of Points for Lambda z (-)                 | 10   | 3.9 (0.7379)     | 18.92    | 3.837    | 19.34        | 4      | [3, 5]          |
|            |              | R Squared Adjusted (-)                            | 9    | 0.9842 (0.01379) | 1.401    | 0.9842   | 1.411        | 0.9893 | [0.9559, 0.999] |
|            |              | Span (-)                                          | 9    | 2.591 (1.059)    | 40.87    | 2.414    | 40.99        | 1.933  | [1.526, 4.182]  |
|            |              | Time Until First Nonzero Conc (h)                 | 10   | 0 (0)            | -^c^     | -^d^     | -^d^         | 0      | [0, 0]          |
|            |              | Time of CMAX (h)                                  | 10   | 3.2 (1.932)      | 60.38    | 2.828    | 52.11        | 2      | [2, 8]          |
|            |              | Time of CMIN Observation (h)                      | 10   | 0 (0)            | -^c^     | -^d^     | -^d^         | 0      | [0, 0]          |
|            |              | Time of Last Nonzero Conc (h)                     | 10   | 24 (0)           | 0        | 24       | 0            | 24     | [24, 24]        |
|            |              | Total CL Obs by F (L/h)                           | 9    | 6.818 (1.44)     | 21.12    | 6.689    | 20.82        | 6.308  | [5.007, 9.004]  |
|            |              | Total CL Pred by F (L/h)                          | 9    | 6.819 (1.444)    | 21.18    | 6.688    | 20.92        | 6.361  | [4.967, 8.975]  |
|            |              | Vz Obs by F (L)                                   | 9    | 64.05 (11.67)    | 18.22    | 63.05    | 19.3         | 62.11  | [45.06, 77.71]  |
|            |              | Vz Pred by F (L)                                  | 9    | 64.05 (11.72)    | 18.3     | 63.05    | 19.32        | 61.92  | [45.07, 78.38]  |
{^a^ Number depends on (reliably) calculated parameters.<br>CV%% = coefficient of variation (%%)=SD/mean*100.<br>Geo-mean: Geometric mean.<br>CV%% geo-mean=(sqrt (exp (variance for log transformed data)-1))*100.<br>^b^ SD not presented when N=1.<br>^c^ CV%% mean not presented when the mean is 0 or N=1.<br>^d^ Geo-mean and CV%% geo-mean not presented when the minimum value is zero or N=1.<br>Values in table are reported with 4 significant digits.<br>IQnca version: 1.3.1.9000<br>Script: compliance<br>Output: output/tables/01_SummaryAll_NCA.rmd<br>Execution date: 2023-12-04 14:26:26.494404}
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**Summary statistics for PK parameters by dose group of Plasma C (C) - Steady-state dose**
!TABINLINE[size:8,ignoreCaption:true,valueTable:false]
| Profile           | Group        | Name (Unit)                                       | N^a^ | Mean (SD)        | CV% mean | Geo-mean | CV% geo-mean | Median | [Min, Max]       |
| ----------------- | ------------ | ------------------------------------------------- | ---- | ---------------- | -------- | -------- | ------------ | ------ | ---------------- |
| Steady-state dose | 10mg_OD_Oral | AUC %Extrapolation Obs (%)                        | 9    | 5.922 (2.68)     | 45.25    | 5.321    | 55.11        | 6.231  | [2.173, 10.3]    |
|                   |              | AUC %Extrapolation Pred (%)                       | 9    | 5.713 (2.558)    | 44.78    | 5.162    | 52.98        | 5.768  | [2.197, 10.27]   |
|                   |              | AUC All (ug/L*h)                                  | 10   | 2804 (742.7)     | 26.49    | 2703     | 30.5         | 2927   | [1526, 3612]     |
|                   |              | AUC Infinity Obs (ug/L*h)                         | 9    | 3060 (758.5)     | 24.79    | 2958     | 29.85        | 3311   | [1627, 3854]     |
|                   |              | AUC Infinity Obs Norm by Dose (ug/L*h/mg)         | 9    | 306 (75.85)      | 24.79    | 295.8    | 29.85        | 331.1  | [162.7, 385.4]   |
|                   |              | AUC Infinity Pred (ug/L*h)                        | 9    | 3055 (763.7)     | 25       | 2951     | 30.15        | 3308   | [1619, 3853]     |
|                   |              | AUC Infinity Pred Norm by Dose (ug/L*h/mg)        | 9    | 305.5 (76.37)    | 25       | 295.1    | 30.15        | 330.8  | [161.9, 385.3]   |
|                   |              | AUC Over Dosing Interval (ug/L*h)                 | 9    | 1805 (340)       | 18.84    | 1774     | 20.07        | 1869   | [1246, 2294]     |
|                   |              | AUC Over Dosing Interval Norm by Dose (ug/L*h/mg) | 9    | 180.5 (34)       | 18.84    | 177.4    | 20.07        | 186.9  | [124.6, 229.4]   |
|                   |              | AUC to Last Nonzero Conc (ug/L*h)                 | 10   | 2804 (742.7)     | 26.49    | 2703     | 30.5         | 2927   | [1526, 3612]     |
|                   |              | AUC to Last Nonzero Conc Norm by Dose (ug/L*h/mg) | 10   | 280.4 (74.27)    | 26.49    | 270.3    | 30.5         | 292.7  | [152.6, 361.2]   |
|                   |              | Average Concentration (ug/L)                      | 9    | 75.2 (14.17)     | 18.84    | 73.94    | 20.07        | 77.86  | [51.93, 95.58]   |
|                   |              | Conc Trough (ug/L)                                | 9    | 29.05 (8.098)    | 27.88    | 27.7     | 36.69        | 31.95  | [12.19, 37.1]    |
|                   |              | Half-Life Lambda z (h)                            | 9    | 44.16 (16.43)    | 37.2     | 41.33    | 41.35        | 44.83  | [22.04, 74.6]    |
|                   |              | Last Nonzero Conc (ug/L)                          | 10   | 2.733 (1.181)    | 43.2     | 2.537    | 41.45        | 2.664  | [1.556, 5.462]   |
|                   |              | Last Nonzero Conc Pred (ug/L)                     | 9    | 2.715 (1.018)    | 37.51    | 2.555    | 38.19        | 2.743  | [1.574, 4.768]   |
|                   |              | Max Conc (ug/L)                                   | 10   | 133.7 (24.57)    | 18.38    | 131.6    | 18.83        | 131.4  | [92.84, 179.5]   |
|                   |              | Max Conc Norm by Dose (ug/L/mg)                   | 10   | 13.37 (2.457)    | 18.38    | 13.16    | 18.83        | 13.14  | [9.284, 17.95]   |
|                   |              | Min Conc (ug/L)                                   | 10   | 25.98 (10.55)    | 40.6     | 23.56    | 53.19        | 31.58  | [9.415, 37.1]    |
|                   |              | Min Conc Norm by Dose (ug/L/mg)                   | 10   | 2.598 (1.055)    | 40.6     | 2.356    | 53.19        | 3.158  | [0.9415, 3.71]   |
|                   |              | Number of Points for Lambda z (-)                 | 10   | 3.2 (0.4216)     | 13.18    | 3.178    | 12.17        | 3      | [3, 4]           |
|                   |              | R Squared Adjusted (-)                            | 9    | 0.9712 (0.03445) | 3.547    | 0.9707   | 3.59         | 0.9866 | [0.9217, 0.9997] |
|                   |              | Span (-)                                          | 9    | 2.461 (0.526)    | 21.38    | 2.41     | 22.2         | 2.453  | [1.609, 3.359]   |
|                   |              | Time Until First Nonzero Conc (h)                 | 10   | 0 (0)            | -^c^     | -^d^     | -^d^         | 0      | [0, 0]           |
|                   |              | Time of CMAX (h)                                  | 10   | 3.6 (0.8433)     | 23.42    | 3.482    | 29.86        | 4      | [2, 4]           |
|                   |              | Time of CMIN Observation (h)                      | 10   | 14.4 (12.39)     | 86.07    | -^d^     | -^d^         | 24     | [0, 24]          |
|                   |              | Time of Last Nonzero Conc (h)                     | 10   | 148.8 (40.48)    | 27.2     | 141.8    | 36.9         | 168    | [72, 168]        |
|                   |              | Total CL by F for Dose Int (L/h)                  | 10   | 5.877 (1.213)    | 20.63    | 5.769    | 20.36        | 5.425  | [4.359, 8.024]   |
|                   |              | Vz for Dose Int at SS by F (L)                    | 9    | 353.1 (120.3)    | 34.07    | 336      | 34.17        | 355.6  | [224.7, 560.9]   |
{^a^ Number depends on (reliably) calculated parameters.<br>CV%% = coefficient of variation (%%)=SD/mean*100.<br>Geo-mean: Geometric mean.<br>CV%% geo-mean=(sqrt (exp (variance for log transformed data)-1))*100.<br>^b^ SD not presented when N=1.<br>^c^ CV%% mean not presented when the mean is 0 or N=1.<br>^d^ Geo-mean and CV%% geo-mean not presented when the minimum value is zero or N=1.<br>Values in table are reported with 4 significant digits.<br>IQnca version: 1.3.1.9000<br>Script: compliance<br>Output: output/tables/01_SummaryAll_NCA.rmd<br>Execution date: 2023-12-04 14:26:26.537803}
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