NCA in R
The IQnca R package
1
Introduction
1.1
What?
1.2
Why?
1.3
Validation?
1.4
Documentation?
1.5
Support?
1.6
Next steps?
2
Installation
2.1
Easy installation
2.2
License
2.3
Source Code
3
Workflow
3.1
Import Data
3.2
Implement Analysis Plan
3.2.1
Ignored observations
3.2.2
Customized AUC intervals
3.2.3
IQRdataNCA export
3.3
Explore and Clean Data
3.4
Present Analysis Data
3.5
Execute NCA
3.6
Present NCA Results
3.7
Statistical analysis
3.8
Reporting
4
Examples
4.1
Example 1
4.1.1
Original data
4.1.2
IQdataNCA object
4.1.3
Parameter calculation and IQnca object
4.2
Example 2
4.2.1
BLQ data handling
4.2.2
Data plots
4.3
Example 3
5
Data Specification
5.1
IQdataNCA function
5.2
IQdataNCA object
6
Method Documentation
6.1
Grouping and profile differentiation
6.2
NCA models
6.3
Pre-dose data handling
6.4
BLQ data handling
6.4.1
For Listings
6.4.2
For Summary Tables and NCA
6.4.3
For Individual and Summary Plots
6.5
Terminal slope calculation
6.5.1
Automatic terminal slope selection
6.6
AUC calculation methods
6.6.1
AUC interval calculus
6.6.2
Concentration interpolation/extrapolation
6.7
Overview of NCA parameters
6.7.1
Last observation defintion
6.7.2
For all profile types
6.7.3
Only for single and first dose profiles
6.7.4
Only for steady-state profiles
6.7.5
Formulas
7
Function Library
8
Release Notes
V0.1.0 February 28, 2021
(c) 2021 IntiQuan GmbH
Noncompartmental Analysis in R
7
Function Library
To be rendered in same way as for IQtools